The Gateway City. Saint Louis is best known as the home of the Gateway Arch, one of the most iconic landmarks in the United States. But there's more to this historic city on the Mississippi River than just that. Saint Louis is a center of culture and commerce, with a rich history dating back to the days of French fur traders and Spanish explorers. The city is full of interesting museums, art galleries, and theaters, and its vibrant nightlife is legendary. There are also plenty of parks and green spaces, as well as a variety of restaurants and cafes to suit every taste. So come and explore Saint Louis, the Gateway to the West.