The city of Heilbronn lies in the heart of the Neckar Valley in the German state of Baden-Württemberg. It is the largest city in the Heilbronn-Franken region and, with almost 120,000 inhabitants, the sixth largest city in the state. Heilbronn is known for its wine industry and is also the home of the Heilbronn University of Applied Sciences. The city was founded by the Celts in the late 4th century BC. The Romans conquered the city in the late 1st century BC and made it the capital of the province of Upper Germany. After the fall of the Western Roman Empire, the city was conquered by the Alemanni. In the 12th century, Heilbronn became a free imperial city. The city was destroyed by a fire in 1442 and rebuilt in the Renaissance style. Heilbronn was the capital of the Württember